Ageing

General theory of ageing and avoiding it. Placeholder.

See also biomarkers.

Lifespan/healthspan/ageing is not my area of research. I’m not qualified to assess in specific detail the outlandish claims made by snake-oil sellers, since I do not know how biology works. That said, I can assess crap statistics and bad reasoning, and I can do that well enough to report that it is sometimes tedious.

There is a danger of pseudoscience and quackery in this area, so beware. The incentives are clearly not great: since cashed-up older persons rarely want to die, selling them on small trials with marginal benefits and low reproducibility is a lucrative enough business to prop up a lot of bad science indefinitely.

1 Life extension

Quantified self/nutrition etc. for lifespan extension. Probably best read in concert with biomarker tracking.

1.1 Sinclair protocol

Berberine, resveratrol, metformin, NAD+ precursors, etc.

See also Does Metformin Work as an Anti-Ageing Drug?

1.2 GlyNAC

This is also on the podcastosphere.

“Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial” (Kumar et al. 2023)